INTERNAL ADAN INFORMATION

• Record: 258
• Number: 143
• Inclusion date: 21-VIII-2004

WHOLE PROTEIN INFORMATION

• Domains within protein: SRC_RSVSR by SMART
• Basic UniProtKB Entry: SRC_RSVSR
• InterPro link: SRC_RSVSR
• Swiss-Prot ENTRY: SRC_RSVSR
• Swiss-Prot AC number: P00524
• Sequence: P00524
• Pfam database: SRC_RSVSR

ALIGNMENT

• BLAST against Swiss-Prot: P00524
• BLAST for whole protein: P00524
• SAS for whole protein: P00524
• BLAST for modular domain: 1SPR
• SAS for domain: 1SPR

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: no ligand 
• iPfam: SH2
• PsiBase: 1SPR
• MINT: whole protein: P00524 or domain: 1SPR
• DOMINO database: P00524
• APID: P00524

• Title: BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS
• Experimental Technique: X-RAY DIFFRACTION
• Resolution Å: 2.5
• Protein Source: Rous sarcoma virus
• Reference: Waksman et al. 1993 Cell 72, 779
• Sequence domain: seqA_1spr2.txt
• Peptide sequence of ligand:
• Biochemical affinity data for: 1spr
• Drugs:
• Phosphorylated residue type: Tyr
• Pfam family: SH2
• Pfam structure: 1SPR
• RCSB_PDB_ID: 1SPR
• SMART: SH2
• PDBsum (domain): 1SPR
• PDBsum (Ligand): 1SPR
• MSD (summary): 1SPR
• MSD (ligands): 1SPR
• Molecular Surface: 1spr

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.