INTERNAL ADAN INFORMATION

• Record: 215
• Number: 100
• Inclusion date: 21-VIII-2004

WHOLE PROTEIN INFORMATION

• Domains within protein: GRB7_HUMAN by SMART
• Basic UniProtKB Entry: GRB7_HUMAN
• InterPro link: GRB7_HUMAN
• Swiss-Prot ENTRY: GRB7_HUMAN
• Swiss-Prot AC number: Q14451
• Sequence: Q14451
• Pfam database: GRB7_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: Q14451
• BLAST for whole protein: Q14451
• SAS for whole protein: Q14451
• BLAST for modular domain: 1MW4
• SAS for domain: 1MW4

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 1MW42_mat 
• iPfam: SH2
• PsiBase: 1MW4
• MINT: whole protein: Q14451 or domain: 1MW4
• DOMINO database: Q14451
• APID: Q14451

• Title: SOLUTION STRUCTURE OF THE HUMAN GRB7-SH2 DOMAIN IN COMPLEX WITH A 10 AMINO ACID PEPTIDE PY1139
• Experimental Technique: NMR, 10 STRUCTURES
• Resolution Å: n/a
• Protein Source: Homo sapiens
• Reference: Ivancic et al. 2003 J.Biomol.NMR 27, 205
• Sequence domain: seqA_1mw42.txt
• Peptide sequence of ligand: PQPEXVNQPD
• Biochemical affinity data for: 1mw4
• Drugs:
• Phosphorylated residue type: Tyr
• Pfam family: SH2
• Pfam structure: 1MW4
• RCSB_PDB_ID: 1MW4
• SMART: SH2
• PDBsum (domain): 1MW4
• PDBsum (Ligand): 1MW4
• MSD (summary): 1MW4
• MSD (ligands): 1MW4
• Molecular Surface: 1mw4

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.