INTERNAL ADAN INFORMATION

• Record: 190
• Number: 62
• Inclusion date: 21-VIII-2004

WHOLE PROTEIN INFORMATION

• Domains within protein: P85A_HUMAN by SMART
• Basic UniProtKB Entry: P85A_HUMAN
• InterPro link: P85A_HUMAN
• Swiss-Prot ENTRY: P85A_HUMAN
• Swiss-Prot AC number: P27986
• Sequence: P27986
• Pfam database: P85A_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P27986
• BLAST for whole protein: P27986
• SAS for whole protein: P27986
• BLAST for modular domain: 1H9O
• SAS for domain: 1H9O

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 1H9O2_mat 
• iPfam: SH2
• PsiBase: 1H9O
• MINT: whole protein: P27986 or domain: 1H9O
• DOMINO database: P27986
• APID: P27986

• Title: PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A
• Experimental Technique: X-RAY DIFFRACTION
• Resolution Å: 1.79
• Protein Source: Homo sapiens
• Reference: Pauptit et al. 2001 Acta Crystallogr D Biol Crystallogr 57, 1397
• Sequence domain: seqA_1h9o2.txt
• Peptide sequence of ligand: XVPML
• Biochemical affinity data for: 1h9o
• Drugs:
• Phosphorylated residue type: Tyr
• Pfam family: SH2
• Pfam structure: 1H9O
• RCSB_PDB_ID: 1H9O
• SMART: SH2
• PDBsum (domain): 1H9O
• PDBsum (Ligand): 1H9O
• MSD (summary): 1H9O
• MSD (ligands): 1H9O
• Molecular Surface: 1h9o

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.