INTERNAL ADAN INFORMATION

• Record: 186
• Number: 58
• Inclusion date: 21-VIII-2004

WHOLE PROTEIN INFORMATION

• Domains within protein: GRB2_HUMAN by SMART
• Basic UniProtKB Entry: GRB2_HUMAN
• InterPro link: GRB2_HUMAN
• Swiss-Prot ENTRY: GRB2_HUMAN
• Swiss-Prot AC number: P62993
• Sequence: P62993
• Pfam database: GRB2_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P62993
• BLAST for whole protein: P62993
• SAS for whole protein: P62993
• BLAST for modular domain: 1FYR
• SAS for domain: 1FYR

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 1FYR2_mat 
• iPfam: SH2
• PsiBase: 1FYR
• MINT: whole protein: P62993 or domain: 1FYR
• DOMINO database: P62993
• APID: P62993

• Title: DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX
• Experimental Technique: X-RAY DIFFRACTION
• Resolution Å: 2.4
• Protein Source: Homo sapiens
• Reference: Schiering et al. 2000 Biochemistry 39, 13376
• Sequence domain: seqA_1fyr2.txt
• Peptide sequence of ligand: XXVNV
• Biochemical affinity data for: 1fyr
• Drugs:
• Phosphorylated residue type: Tyr
• Pfam family: SH2
• Pfam structure: 1FYR
• RCSB_PDB_ID: 1FYR
• SMART: SH2
• PDBsum (domain): 1FYR
• PDBsum (Ligand): 1FYR
• MSD (summary): 1FYR
• MSD (ligands): 1FYR
• Molecular Surface: 1fyr

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.