INTERNAL ADAN INFORMATION

• Record: 1637
• Number: 223
• Inclusion date: 30-V-2006

WHOLE PROTEIN INFORMATION

• Domains within protein: LCK_HUMAN by SMART
• Basic UniProtKB Entry: LCK_HUMAN
• InterPro link: LCK_HUMAN
• Swiss-Prot ENTRY: LCK_HUMAN
• Swiss-Prot AC number: P06239
• Sequence: P06239
• Pfam database: LCK_HUMAN

ALIGNMENT

• BLAST against Swiss-Prot: P06239
• BLAST for whole protein: P06239
• SAS for whole protein: P06239
• BLAST for modular domain: 1X27
• SAS for domain: 1X27

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: 1X273_mat 
• iPfam: SH2
• PsiBase: 1X27
• MINT: whole protein: P06239 or domain: 1X27
• DOMINO database: P06239
• APID: P06239

• Title: Crystal structure of lck sh2-sh3 with sh2 binding site of p130cas
• Experimental Technique: X-RAY DIFFRACTION
• Resolution Å: 2.7
• Protein Source: Homo sapiens
• Reference: Nasertorabi et al., 2006 J.Mol.Recog. 19, 30
• Sequence domain: seqA_1x272.txt
• Peptide sequence of ligand: YDYV
• Biochemical affinity data for: 1x27
• Drugs:
• Phosphorylated residue type: Tyr
• Pfam family: SH2
• Pfam structure: 1X27
• RCSB_PDB_ID: 1X27
• SMART: SH2
• PDBsum (domain): 1X27
• PDBsum (Ligand): 1X27
• MSD (summary): 1X27
• MSD (ligands): 1X27
• Molecular Surface: 1x27

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.