INTERNAL ADAN INFORMATION

• Record: 1378
• Number: 300
• Inclusion date: 12-VI-2006

WHOLE PROTEIN INFORMATION

• Domains within protein: P43405 by SMART
• Basic UniProtKB Entry: P43405
• InterPro link: P43405
• Swiss-Prot ENTRY: P43405
• Swiss-Prot AC number: P43405
• Sequence: P43405
• Pfam database: P43405

ALIGNMENT

• BLAST against Swiss-Prot: P43405
• BLAST for whole protein: P43405
• SAS for whole protein: P43405
• BLAST for modular domain: 1XBA
• SAS for domain: 1XBA

PREDICTED INTERACTIONS AND EXPERIMENTAL DATA

• FoldX Results: no ligand 
• iPfam: kinase
• PsiBase: 1XBA
• MINT: whole protein: P43405 or domain: 1XBA
• DOMINO database: P43405
• APID: P43405

• Title: A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
• Experimental Technique: X-RAY DIFFRACTION
• Resolution Å: 2
• Protein Source: Homo sapiens
• Reference: 15507431
• Sequence domain: seqA_1XBA2.txt
• Peptide sequence of ligand:
• Biochemical affinity data for: 1XBA
• Drugs:
• Phosphorylated residue type:
• Pfam family: kinase
• Pfam structure: 1XBA
• RCSB_PDB_ID: 1XBA
• SMART: kinase
• PDBsum (domain): 1XBA
• PDBsum (Ligand): 1XBA
• MSD (summary): 1XBA
• MSD (ligands): 1XBA
• Molecular Surface: 1XBA

PDB1: Original Protein Data Bank file.

PDB2: Simplified coordinate files.