• Protein family: PTB
• Protein number: 1
• Peptide number: 100

Protein:

• Protein name: shc
• Protein source: Homo Sapiens

Structural information:

• PDB apo: 1oy2
• Experimental technique apo: NMR
• Resolution apo (Å):
• PDB complex: 1shc
• Experimental technique complex: NMR, min. av. Str.
• Resolution complex (Å):

Peptide:

• Name of peptide (in paper): Trk490
• Phosphorylated residue type: Tyr
• Origin protein of peptide: TrkA
• Source of origin protein: Homo Sapiens
• Phosphorylated residue number in origin protein: 490
• First position before phosphorylated residue: 10
• Last position before phosphorylated residue: 7
• Sequence of peptide: LQGHIIENPQpYFSDACVH
• N-terminus: Free
• C-terminus: Free
• Peptide length: 18

Mutational information:

• wt or mutant peptide: wt
• Position of mutation in peptide:
• Mutated residue in peptide:
• New residue in peptide:
• wt or mutant protein: wt
• Position of mutation in protein:
• Mutated residue in protein:
• New residue in protein:

Thermodynamic information:

• Kdiss (mM): 0.042
• Km (M):
• IC50 (M):
• DGdiss (kJ/mol), experimental: -42.1
• DGdiss (kJ/mol), calculated with FOLDx:
• DDGdiss (kJ/mol):

Experimental conditions:

• Method: ITC
• Temperature ºC: 25
• pH: 7.5
• Buffer conditions: 100 mM Hepes, 100 mM NaCl, 1 mM DTT

Bibliography:

• Reference: Mandiyan et al. 1996 JBC 271, 4770
• MedLine_ID: 8617744