• Protein family: SH2
• Protein number: 25
• Peptide number: 203

Protein:

• Protein name: Src
• Protein source: Homo Sapiens

Structural information:

• PDB apo: 1fmk
• Experimental technique apo: X-ray
• Resolution apo (Å): 1.5
• PDB complex: 1fmk
• Experimental technique complex:
• Resolution complex (Å):

Peptide:

• Name of peptide (in paper): P2
• Phosphorylated residue type: Tyr
• Origin protein of peptide: FAK
• Source of origin protein:
• Phosphorylated residue number in origin protein:
• First position before phosphorylated residue: -7
• Last position before phosphorylated residue: 5
• Sequence of peptide: SVSETDDpYAEIID
• N-terminus: Free
• C-terminus: Free
• Peptide length: 13

Mutational information:

• wt or mutant peptide: wt
• Position of mutation in peptide:
• Mutated residue in peptide:
• New residue in peptide:
• wt or mutant protein: wt
• Position of mutation in protein:
• Mutated residue in protein:
• New residue in protein:

Thermodynamic information:

• Kdiss (mM): 0.033
• Km (M):
• IC50 (M):
• DGdiss (kJ/mol), experimental: -41.98
• DGdiss (kJ/mol), calculated with FOLDx:
• DDGdiss (kJ/mol):

Experimental conditions:

• Method: SPR
• Temperature ºC: 20
• pH: 7.4
• Buffer conditions: 10 mM Hepes, 150 mM NaCl, P20 surfactant

Bibliography:

• Reference: Thomas et al. 1998 JBC 273, 577
• MedLine_ID: 9417118