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Matrix information:
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ADAN-name: 2C1N2.PDB
Scoring matrix: 2C1N2_mat
Uniprot code: P63104
Genome source: Homo sapiens
Wild-type ligand: ARKsTGGK
Foldx wt ligand score: 6.62
Foldx random average score for Homo sapiens: 11.824 Available information for P63104 in MINT (Nov 2008):
Nš of interacting proteins: 310
Proteins belonging to other specie: 3
Nš of interactions described: 374
Interactions with other species: 6
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7744
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40317
Total fragments: 18291407
Proteins after random average filtering: 40304
Total fragments: 9404887
Proteins after disorder filtering: 30578
Total fragments: 908910
Proteins after pattern filtering: 3717
Total fragments: 7891
Proteins after MINT filtering: 33
Total fragments: 96
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
ARKsTGGK |
6.62
|
-9.13 |
0.00 |
| Best peptides |
GFIsGGWW |
0.00
|
-11.39 |
-2.26 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q08211 |
GFRGNSGG |
6.91
|
-8.80 |
0.33 |
|
RGNSGGDY |
8.36
|
-7.10 |
2.03 |
|
YRGPSGGY |
9.46
|
-6.27 |
2.86 |
| Q5T200 |
QKRSSSLG |
8.89
|
-9.40 |
-0.27 |
|
RSHTSGRL |
9.80
|
-7.17 |
1.96 |
|
RSSSLGSN |
10.34
|
-6.42 |
2.71 |
| Q9NPI6 |
RKASSPSP |
11.56
|
-4.48 |
4.65 |
| P49327 |
ILRPNTQP |
9.68
|
-7.52 |
1.61 |
| P58340 |
RMRSVGHE |
8.83
|
-9.86 |
-0.73 |
|
TRMRSVGH |
11.64
|
-6.38 |
2.75 |
| P16471 |
WWRPGTDG |
9.67
|
-6.62 |
2.51 |
|
RPGTDGGL |
11.20
|
-6.92 |
2.21 |
| Q9UDY2 |
QLRDNSPP |
9.70
|
-7.64 |
1.49 |
|
RLNSHGGR |
9.77
|
-6.45 |
2.68 |
|
RSRLNSHG |
11.40
|
-7.23 |
1.90 |
| O75044 |
TFRSDSHG |
8.64
|
-10.37 |
-1.24 |
|
SCRPSSQP |
9.91
|
-7.10 |
2.03 |
| P30304 |
NERDSSEP |
10.79
|
-10.56 |
-1.43 |
| Q7KZI7 |
VPRPSTAP |
11.41
|
-7.87 |
1.26 |
| Q86YZ3 |
RSSSSGRH |
9.71
|
-6.30 |
2.83 |
|
RSSSSGQH |
9.74
|
-7.18 |
1.95 |
|
FGRSSSSG |
9.77
|
-6.70 |
2.43 |
| Q7Z6B7 |
RSTSSGQY |
9.25
|
-7.35 |
1.78 |
|
IRRSTSSG |
11.08
|
-6.46 |
2.67 |
| O43524 |
MQRSSSFP |
8.58
|
-8.14 |
0.99 |
|
QRSSSFPY |
11.35
|
-7.16 |
1.97 |
| Q9Y4H2 |
RPWTPGQP |
10.80
|
-9.71 |
-0.58 |
| Q6PKG0 |
RHSSNPPL |
11.49
|
-5.09 |
4.04 |
|
TRHSSNPP |
11.52
|
-6.65 |
2.48 |
| Q6DD88 |
SWRGGSDP |
9.59
|
-9.17 |
-0.04 |
| P49815 |
RSMSGGHG |
8.02
|
-7.74 |
1.39 |
|
VRSMSGGH |
9.20
|
-7.33 |
1.80 |
| Q14432 |
RPYSQGNP |
8.75
|
-8.78 |
0.35 |
|
CGRPYSQG |
11.53
|
-6.05 |
3.08 |
| O96013 |
SSREGSGG |
6.63
|
-7.97 |
1.16 |
|
DKRPLSGP |
9.11
|
-7.45 |
1.68 |
|
SREGSGGP |
10.08
|
-6.81 |
2.32 |
| Q14764 |
GRRVASGP |
9.08
|
-8.37 |
0.76 |
|
RRVASGPS |
10.26
|
-8.43 |
0.70 |
|
RVASGPSP |
11.00
|
-6.75 |
2.38 |
| O00571 |
GSRSDSRG |
10.32
|
-7.89 |
1.24 |
| Q7L8J4 |
GRRGSDGG |
9.86
|
-7.98 |
1.15 |
|
GGRRGSDG |
10.22
|
-7.34 |
1.79 |
|
RRGSDGGA |
10.30
|
-7.26 |
1.87 |
| Q15154 |
DQRSTSAP |
9.97
|
-9.16 |
-0.03 |
| Q5VV41 |
GNRSSSVP |
8.46
|
-8.12 |
1.01 |
| O60825 |
RNYSVGSR |
8.32
|
-8.69 |
0.44 |
| Q9UQL6 |
SRTQSSPL |
10.40
|
-5.75 |
3.38 |
| Q6Y7W6 |
RGRSSSRG |
9.71
|
-7.99 |
1.14 |
|
GRSSSRGR |
10.97
|
-9.32 |
-0.19 |
|
RSSSRGRG |
11.67
|
-7.37 |
1.76 |
| O60292 |
ALREHSNP |
8.76
|
-7.05 |
2.08 |
|
SKRPVSFP |
10.19
|
-6.80 |
2.33 |
|
REHSNPSP |
11.66
|
-6.36 |
2.77 |
| O95644 |
GRGETLGP |
8.82
|
-8.00 |
1.13 |
|
RGETLGPA |
11.76
|
-6.24 |
2.89 |
| P47736 |
RKKSGPFG |
10.15
|
-7.32 |
1.81 |
|
TRKKSGPF |
10.41
|
-7.20 |
1.93 |
| Q8WUI4 |
SRAQSSPA |
10.17
|
-5.32 |
3.81 |
| P15056 |
RDRSSSAP |
10.38
|
-7.59 |
1.54 |
| P34931 |
PGRPATGP |
10.95
|
-4.69 |
4.44 |
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