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Matrix information:
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ADAN-name: 1IB12.PDB
Scoring matrix: 1IB12_mat
Uniprot code: P63104
Genome source: Homo sapiens
Wild-type ligand: SGIPGSPGRQRRHpLPANE
Foldx wt ligand score: 13.13
Foldx random average score for Homo sapiens: 24.217 Available information for P63104 in MINT (Nov 2008):
Nš of interacting proteins: 310
Proteins belonging to other specie: 3
Nš of interactions described: 374
Interactions with other species: 6
Genome scanning information:
Subcellular location: True
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 7744
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 40317
Total fragments: 17848242
Proteins after random average filtering: 40240
Total fragments: 10058671
Proteins after disorder filtering: 22174
Total fragments: 401135
Proteins after pattern filtering: 3175
Total fragments: 13505
Proteins after MINT filtering: 24
Total fragments: 170
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
SGIPGSPGRQRRHpLPANE |
13.13
|
-20.24 |
0.00 |
| Best peptides |
KFRyGRsKRRyMYEMFCNL |
0.00
|
-18.98 |
1.26 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q08211 |
RAGYGAGVGGGYRGVSRGG |
18.93
|
-7.99 |
12.25 |
|
AGVGGGYRGVSRGGFRGNS |
19.18
|
-10.10 |
10.14 |
|
RGPSGGYRGSGGFQRGGGR |
19.55
|
-8.23 |
12.01 |
| Q5T200 |
LSSPQRKQSPPRHRSPMRE |
19.91
|
-12.88 |
7.36 |
|
PYPSHSLSSPQRKQSPPRH |
20.24
|
-13.39 |
6.85 |
|
SNRSNRSHTSGRLRSPSND |
20.90
|
-10.26 |
9.98 |
| Q14432 |
CSSCGRPYSQGNPADEPLE |
19.27
|
-10.88 |
9.36 |
|
RPYSQGNPADEPLERSGVA |
19.56
|
-13.07 |
7.17 |
|
PPVICSSCGRPYSQGNPAD |
20.45
|
-10.36 |
9.88 |
| P58340 |
RHNLGNTRMRSVGHENPGS |
18.84
|
-17.05 |
3.19 |
|
HNLGNTRMRSVGHENPGSR |
19.48
|
-12.38 |
7.86 |
| Q9UDY2 |
SRLNSHGGRSRSWEDSPER |
17.52
|
-15.15 |
5.09 |
|
RLNSHGGRSRSWEDSPERG |
19.61
|
-18.08 |
2.16 |
|
DQLRDNSPPPAFKPEPPKA |
19.64
|
-15.76 |
4.48 |
| O75044 |
SPGVGASCRPSSQPIMSQS |
18.81
|
-14.22 |
6.02 |
|
GASCRPSSQPIMSQSLPKE |
20.47
|
-13.55 |
6.69 |
|
GVGASCRPSSQPIMSQSLP |
23.02
|
-11.32 |
8.92 |
| P25054 |
TMPPSRSKTPPPPPQTAQT |
21.67
|
-14.18 |
6.06 |
| P30304 |
NERDSSEPGNFIPLFTPQS |
21.62
|
-12.02 |
8.22 |
| Q7KZI7 |
VPRPSTAPQRVPVASPSAH |
19.82
|
-10.74 |
9.50 |
|
LERKKTTPTPSTNSVLSTS |
22.16
|
-9.26 |
10.98 |
|
KVPASPLPGLERKKTTPTP |
22.43
|
-11.69 |
8.55 |
| Q86YZ3 |
GSGSGRSSSRGPYESRSGH |
14.08
|
-14.31 |
5.93 |
|
GYGSGRSSSRGPYESGSGH |
14.12
|
-15.12 |
5.12 |
|
GSGSGRSSSRGPYESRLGH |
16.06
|
-14.32 |
5.92 |
| Q7Z6B7 |
RRSTSSGQYTGFNDHKPLD |
18.53
|
-12.66 |
7.58 |
|
SPPIRRSTSSGQYTGFNDH |
21.22
|
-11.62 |
8.62 |
|
PPIRRSTSSGQYTGFNDHK |
23.32
|
-11.58 |
8.66 |
| O43524 |
TGGLMQRSSSFPYTTKGSG |
18.68
|
-12.48 |
7.76 |
|
GGLMQRSSSFPYTTKGSGL |
21.18
|
-12.05 |
8.19 |
|
SPTGGLMQRSSSFPYTTKG |
22.20
|
-10.83 |
9.41 |
| Q9Y4H2 |
PAPPLAPQGRPWTPGQPGG |
18.18
|
-13.61 |
6.63 |
|
QGRPWTPGQPGGLVGCPGS |
20.16
|
-9.84 |
10.40 |
|
GRPWTPGQPGGLVGCPGSG |
21.35
|
-8.19 |
12.05 |
| O96013 |
RPKSSREGSGGPQESSRDK |
20.96
|
-11.08 |
9.16 |
|
NSLRRDSPPPPARARQENG |
21.45
|
-10.70 |
9.54 |
|
SREGSGGPQESSRDKRPLS |
22.08
|
-10.60 |
9.64 |
| Q14764 |
GQPLGRRVASGPSPGEGIS |
21.84
|
-8.94 |
11.30 |
|
RVASGPSPGEGISPQSAQA |
22.71
|
-11.12 |
9.12 |
|
GMGPEGQPLGRRVASGPSP |
22.78
|
-8.44 |
11.80 |
| O00571 |
GSRSDSRGKSSFFSDRGSG |
20.12
|
-9.23 |
11.01 |
|
KDKDAYSSFGSRSDSRGKS |
20.91
|
-10.62 |
9.62 |
|
FGSRSDSRGKSSFFSDRGS |
21.01
|
-10.68 |
9.56 |
| Q7L8J4 |
DGQELGTRSGGRRGSDGGA |
20.56
|
-10.65 |
9.59 |
|
GQELGTRSGGRRGSDGGAR |
21.81
|
-8.28 |
11.96 |
| Q15154 |
VDQRSTSAPSASVGLAPVV |
21.98
|
-9.36 |
10.88 |
|
RSTSAPSASVGLAPVVNGE |
22.20
|
-10.93 |
9.31 |
|
QRSVDQRSTSAPSASVGLA |
23.37
|
-9.15 |
11.09 |
| O60825 |
PLSSSNTIRRPRNYSVGSR |
19.19
|
-11.11 |
9.13 |
|
SSNTIRRPRNYSVGSRPLK |
21.28
|
-11.40 |
8.84 |
|
LSSSNTIRRPRNYSVGSRP |
22.27
|
-12.23 |
8.01 |
| Q6Y7W6 |
GAPRGRSSSRGRGRGRGEC |
20.99
|
-7.24 |
13.00 |
|
GTVVGAPRGRSSSRGRGRG |
21.27
|
-7.47 |
12.77 |
|
RGGGGTVVGAPRGRSSSRG |
23.39
|
-6.51 |
13.73 |
| O60292 |
SKRPVSFPETPYTVSPAGA |
21.05
|
-11.57 |
8.67 |
|
HSKRPVSFPETPYTVSPAG |
23.07
|
-10.00 |
10.24 |
|
RPVSFPETPYTVSPAGADR |
23.71
|
-10.47 |
9.77 |
| O95644 |
AAVFGRGETLGPAPRAGGT |
18.92
|
-8.52 |
11.72 |
|
GPAAAVFGRGETLGPAPRA |
23.09
|
-10.65 |
9.59 |
|
PLGPAAAVFGRGETLGPAP |
23.49
|
-8.19 |
12.05 |
| O00750 |
SKDTSGKPVARSKTMPPQV |
19.87
|
-13.64 |
6.60 |
|
SGKPVARSKTMPPQVPPRT |
21.72
|
-15.77 |
4.47 |
|
VARSKTMPPQVPPRTYASR |
22.91
|
-10.07 |
10.17 |
| Q8WUI4 |
LHWPLSRTRSEPLPPSATA |
23.39
|
-10.00 |
10.24 |
|
SGLHWPLSRTRSEPLPPSA |
24.05
|
-8.79 |
11.45 |
|
