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Matrix information:
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ADAN-name: 2C232.PDB
Scoring matrix: 2C232_mat
Uniprot code: P31946
Genome source: Homo sapiens
Wild-type ligand: GLLDALDLASK
Foldx wt ligand score: 6.74
Foldx random average score for Homo sapiens: 24.814 Available information for P31946 in MINT (Nov 2008):
Nš of interacting proteins: 88
Proteins belonging to other specie: 3
Nš of interactions described: 120
Interactions with other species: 7
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having weird amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22056464
Proteins after random average filtering: 48038
Total fragments: 12762581
Proteins after disorder filtering: 35264
Total fragments: 1200986
Proteins after pattern filtering: 4964
Total fragments: 16717
Proteins after MINT filtering: 24
Total fragments: 133 ROC parameters:
TPR= 0.273
FPR= 0.103
ACC= 0.896
SPC= 0.897
MCC= 0.024 Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
GLLDALDLASK |
6.74
|
-16.38 |
0.00 |
| Best peptides |
RDMEAMyLLGH |
0.00
|
-13.59 |
2.79 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| Q7Z401 |
CRRSSLPPNSP |
16.42
|
-10.21 |
6.17 |
|
ACRRSSLPPNS |
18.91
|
-7.45 |
8.93 |
|
RPPSTGVMECR |
21.35
|
-10.38 |
6.00 |
| P19634 |
RIQRCLSDPGP |
14.49
|
-9.55 |
6.83 |
|
PRERSIGDVTT |
19.15
|
-7.73 |
8.65 |
|
QRCLSDPGPHP |
19.41
|
-8.54 |
7.84 |
| Q53ET0 |
LTHCSRHGSGP |
18.32
|
-6.24 |
10.14 |
|
SRHGSGPNIIL |
18.39
|
-6.51 |
9.87 |
|
CSRHGSGPNII |
20.35
|
-1.19 |
15.19 |
| Q8N3F8 |
LAPRTRGSSGP |
19.56
|
-7.24 |
9.14 |
|
TRGSSGPQPAK |
20.71
|
-4.43 |
11.95 |
|
PGTRSGTRPGP |
20.88
|
-5.62 |
10.76 |
| Q14739 |
SRSRSRSPGRP |
19.72
|
-8.34 |
8.04 |
|
RSRSPGRPPKS |
23.66
|
-2.28 |
14.10 |
| Q86X29 |
RSSSAGGQGSY |
15.31
|
-8.34 |
8.04 |
|
DRSSSAGGQGS |
16.64
|
-4.87 |
11.51 |
|
VDRSSSAGGQG |
16.79
|
-7.27 |
9.11 |
| Q9Y2U5 |
RMPRAQSYPDN |
16.21
|
-10.75 |
5.63 |
|
SRDRSSPPPGY |
20.61
|
-6.01 |
10.37 |
|
KSRMPRAQSYP |
22.32
|
-9.22 |
7.16 |
| Q9UDY2 |
YSERSRLNSHG |
18.31
|
-9.26 |
7.12 |
|
RSRLNSHGGRS |
19.54
|
-5.37 |
11.01 |
|
ERSRLNSHGGR |
21.78
|
-5.30 |
11.08 |
| P30304 |
NERDSSEPGNF |
15.07
|
-10.50 |
5.88 |
|
ERDSSEPGNFI |
22.29
|
-4.06 |
12.32 |
|
SNERDSSEPGN |
23.92
|
-5.47 |
10.91 |
| Q7KZI7 |
VPRPSTAPQRV |
19.89
|
-7.88 |
8.50 |
|
ERKKTTPTPST |
20.93
|
-6.46 |
9.92 |
|
RKKTTPTPSTN |
24.18
|
-8.55 |
7.83 |
| P49796 |
RNESPGAPPAG |
23.19
|
-4.07 |
12.31 |
| Q9Y4H2 |
RPWTPGQPGGL |
17.98
|
-9.06 |
7.32 |
| Q6PKG0 |
TRHSSNPPLES |
16.01
|
-12.77 |
3.61 |
|
KTRHSSNPPLE |
20.93
|
-5.21 |
11.17 |
| P10636 |
ARGPSLGEDTK |
15.74
|
-8.14 |
8.24 |
|
EGPEARGPSLG |
17.06
|
-8.01 |
8.37 |
|
SSAKSRLQTAP |
18.73
|
-10.09 |
6.29 |
| P49815 |
RSMSGGHGLRV |
15.90
|
-7.92 |
8.46 |
|
VRSMSGGHGLR |
18.10
|
-7.87 |
8.51 |
| O43143 |
KRAGTDGKDRD |
15.29
|
-4.73 |
11.65 |
|
GKKRAGTDGKD |
19.68
|
-8.00 |
8.38 |
|
KKRAGTDGKDR |
20.32
|
-10.05 |
6.33 |
| Q99570 |
KRNGSLPDCPP |
22.89
|
-12.54 |
3.84 |
| Q9UQ35 |
RSRSATPPATR |
16.29
|
-10.49 |
5.89 |
|
RSRSGSSPGLR |
17.49
|
-7.36 |
9.02 |
|
SRSGSSPGLRD |
18.51
|
-2.67 |
13.71 |
| P55196 |
RSSDGRPDSGG |
16.05
|
-12.37 |
4.01 |
|
GRPDSGGTLRI |
16.94
|
-8.09 |
8.29 |
|
RPASDGVFLSN |
18.84
|
-5.56 |
10.82 |
| P30291 |
PLPPARSPTEP |
21.04
|
-9.59 |
6.79 |
|
RRRSPGPAPGS |
21.55
|
-6.34 |
10.04 |
|
ARSPTEPGPER |
24.34
|
-6.64 |
9.74 |
| Q15569 |
PARRCRSLPSS |
17.85
|
-9.72 |
6.66 |
|
RRCRSLPSSPE |
22.56
|
-14.41 |
1.97 |
|
ARRCRSLPSSP |
23.24
|
-7.71 |
8.67 |
| O75592 |
RAESPGPGSRL |
21.62
|
-7.67 |
8.71 |
|
SRAESPGPGSR |
23.12
|
-5.52 |
10.86 |
|
SSSRAESPGPG |
24.58
|
-6.95 |
9.43 |
| P15056 |
FGQRDRSSSAP |
22.49
|
-6.72 |
9.66 |
| Q96SB4 |
RPPPARPLTRP |
18.05
|
-8.88 |
7.50 |
|
PLTRPETPPAH |
23.99
|
-6.51 |
9.87 |
|
PPARPLTRPET |
24.58
|
-7.36 |
9.02 |
|
