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Matrix information:
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ADAN-name: 1FYN2.PDB
Scoring matrix: 1FYN2_mat
Uniprot code: P06241
Genome source: Homo sapiens
Wild-type ligand: PPAYPPPPVP
Foldx wt ligand score: 6.58
Foldx random average score for Homo sapiens: 13.805 Available information for P06241 in MINT (Nov 2008):
Nš of interacting proteins: 29
Proteins belonging to other specie: 8
Nš of interactions described: 52
Interactions with other species: 15
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22104514
Proteins after random average filtering: 48039
Total fragments: 11458467
Proteins after disorder filtering: 35876
Total fragments: 1312472
Proteins after pattern filtering: 25987
Total fragments: 463830
Proteins after MINT filtering: 16
Total fragments: 655
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
PPAYPPPPVP |
6.58
|
-10.76 |
0.00 |
| Best peptides |
RPKGFPPDNM |
0.00
|
-10.43 |
0.33 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P54253 |
APGLITPGSP |
6.46
|
-10.61 |
0.15 |
|
TPGSPPPAQQ |
6.59
|
-9.29 |
1.47 |
|
TPQPGTPVSP |
7.27
|
-10.20 |
0.56 |
| P11137 |
VPGIDLPKEP |
5.96
|
-11.75 |
-0.99 |
|
LPKEPPTPKE |
6.75
|
-9.92 |
0.84 |
|
TPGTPPSYSS |
7.92
|
-7.63 |
3.13 |
| O15117 |
KPVGPKPINL |
4.78
|
-9.64 |
1.12 |
|
TPKQKPLPPL |
6.38
|
-10.54 |
0.22 |
|
FTLGPPPPKP |
6.55
|
-10.55 |
0.21 |
| P22681 |
RPIPKVPVSA |
6.26
|
-10.82 |
-0.06 |
|
KPLPVPPTLR |
6.36
|
-9.75 |
1.01 |
|
VPKLPPGEQC |
6.38
|
-11.14 |
-0.38 |
| Q07666 |
IPLPPPPAPE |
6.10
|
-10.87 |
-0.11 |
|
SPATQPPPLL |
6.52
|
-8.36 |
2.40 |
|
RGRGAAPPPP |
6.67
|
-8.77 |
1.99 |
| Q13283 |
RPESKPESQI |
6.33
|
-11.72 |
-0.96 |
|
GPGGPRGGLG |
7.14
|
-7.06 |
3.70 |
|
PPQRGPRPIR |
7.37
|
-10.36 |
0.40 |
| P25445 |
FCHKPCPPGE |
9.96
|
-7.81 |
2.95 |
|
KPCPPGERKA |
11.17
|
-6.53 |
4.23 |
|
GQFCHKPCPP |
11.52
|
-6.81 |
3.95 |
| Q13444 |
PPRKPLPADP |
6.47
|
-12.98 |
-2.22 |
|
RPAPPPPTVS |
6.51
|
-11.68 |
-0.92 |
|
GPAKPPPPRK |
6.74
|
-10.61 |
0.15 |
| P42768 |
TPRGPPPPGR |
3.79
|
-11.63 |
-0.87 |
|
RRGGLPPLPL |
5.08
|
-10.79 |
-0.03 |
|
VPLGIAPPPP |
5.22
|
-11.11 |
-0.35 |
| P16333 |
KPSVPDSASP |
10.20
|
-6.99 |
3.77 |
|
KVKRKPSVPD |
10.51
|
-9.39 |
1.37 |
|
KRKPSVPDSA |
10.68
|
-8.63 |
2.13 |
| Q9Y5K6 |
KPKKPPPPAK |
5.13
|
-12.55 |
-1.79 |
|
RPEKPVPPPP |
5.56
|
-13.84 |
-3.08 |
|
FPKPKKPPPP |
5.85
|
-13.26 |
-2.50 |
| P29353 |
LPVGQPVGGD |
5.69
|
-9.29 |
1.47 |
|
FPGKEPPLGG |
5.85
|
-9.98 |
0.78 |
|
MPESGPLPLL |
7.05
|
-9.70 |
1.06 |
| P12931 |
FPASQTPSKP |
7.39
|
-11.95 |
-1.19 |
|
TPSKPASADG |
10.72
|
-6.70 |
4.06 |
|
PASQTPSKPA |
11.67
|
-6.36 |
4.40 |
| P06729 |
RPRVQPKPPH |
4.52
|
-9.98 |
0.78 |
|
LPRPRVQPKP |
6.54
|
-13.84 |
-3.08 |
|
PPLPRPRVQP |
6.80
|
-10.25 |
0.51 |
| P35968 |
GPQPLPIHVG |
8.76
|
-7.48 |
3.28 |
| Q13177 |
FPSGTPALNA |
4.67
|
-9.50 |
1.26 |
|
PPAPPVRMSS |
9.78
|
-8.71 |
2.05 |
|
KPPAPPVRMS |
10.00
|
-8.28 |
2.48 |
|
