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Matrix information:
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ADAN-name: 1BBZ2.PDB
Scoring matrix: 1BBZ2_mat
Uniprot code: P00519
Genome source: Homo sapiens
Wild-type ligand: APSYSPPPPP
Foldx wt ligand score: 1.36
Foldx random average score for Homo sapiens: 10.412 Available information for P00519 in MINT (Nov 2008):
Nš of interacting proteins: 29
Proteins belonging to other specie: 2
Nš of interactions described: 54
Interactions with other species: 4
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22104514
Proteins after random average filtering: 48039
Total fragments: 11426801
Proteins after disorder filtering: 35373
Total fragments: 1409072
Proteins after pattern filtering: 26077
Total fragments: 532153
Proteins after MINT filtering: 20
Total fragments: 1303
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
APSYSPPPPP |
1.36
|
-13.41 |
0.00 |
| Best peptides |
PPRYGPMGMP |
0.00
|
-12.18 |
1.23 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| P06400 |
PPAPPPPPPP |
3.82
|
-11.86 |
1.55 |
|
APPPPPPPEE |
4.99
|
-11.17 |
2.24 |
|
PPTLSPIPHI |
5.28
|
-10.35 |
3.06 |
| P00533 |
PVYHNQPLNP |
6.40
|
-9.70 |
3.71 |
|
CPTNGPKIPS |
6.66
|
-8.88 |
4.53 |
|
PLNPAPSRDP |
6.85
|
-8.35 |
5.06 |
| O14746 |
PPSTSRPPRP |
5.34
|
-10.76 |
2.65 |
|
PLGLPAPGAR |
6.11
|
-8.03 |
5.38 |
|
PPRPWDTPCP |
6.43
|
-9.33 |
4.08 |
| O15399 |
PPPAKPPPPP |
3.50
|
-11.93 |
1.48 |
|
PPAAQPPQKP |
3.69
|
-11.45 |
1.96 |
|
SPAYPAPGPA |
4.24
|
-10.60 |
2.81 |
| P22681 |
PQASLPPVPP |
4.88
|
-10.02 |
3.39 |
|
APQASLPPVP |
4.99
|
-10.84 |
2.57 |
|
PVPKLPPGEQ |
5.26
|
-9.83 |
3.58 |
| P18031 |
PPEHIPPPPR |
4.40
|
-11.64 |
1.77 |
|
PPPRPPKRIL |
4.92
|
-11.11 |
2.30 |
|
PPPPRPPKRI |
5.02
|
-11.09 |
2.32 |
| Q92558 |
PPPPVPPPPP |
3.64
|
-12.35 |
1.06 |
|
PPPVPPPPPP |
3.77
|
-11.61 |
1.80 |
|
PPPPPPPPLP |
3.77
|
-12.64 |
0.77 |
| O15162 |
PVGYPPQYPP |
2.83
|
-10.04 |
3.37 |
|
PPQYPPTAFQ |
4.19
|
-10.19 |
3.22 |
|
QVSYPPPPAG |
5.26
|
-7.17 |
6.24 |
| P12931 |
FPASQTPSKP |
7.64
|
-8.17 |
5.24 |
|
PASQTPSKPA |
7.95
|
-7.66 |
5.75 |
|
PSKPASADGH |
9.11
|
-3.74 |
9.67 |
| Q8IZP0 |
PPSGAPPAPP |
3.49
|
-11.96 |
1.45 |
|
PPTQKPPSPP |
3.51
|
-11.27 |
2.14 |
|
PPPSGAPPAP |
4.28
|
-11.19 |
2.22 |
| Q13671 |
PPAVPPPPVP |
4.00
|
-11.41 |
2.00 |
|
PLSPPAVPPP |
5.38
|
-9.28 |
4.13 |
|
PPPPVPVLPG |
5.62
|
-10.92 |
2.49 |
| P04626 |
APQPHPPPAF |
5.25
|
-10.53 |
2.88 |
|
PRSPLAPSEG |
6.27
|
-8.38 |
5.03 |
|
CHPCSPMCKG |
6.81
|
-7.34 |
6.07 |
| P21860 |
GPGIAPGPEP |
5.49
|
-9.30 |
4.11 |
|
PLHPVPIMPT |
5.50
|
-8.99 |
4.42 |
|
CPLHPVPIMP |
6.65
|
-11.16 |
2.25 |
| P04637 |
PPVAPAPAAP |
4.81
|
-10.48 |
2.93 |
|
APAPAAPTPA |
5.77
|
-8.52 |
4.89 |
|
APTPAAPAPA |
5.84
|
-8.98 |
4.43 |
| O15350 |
PPSYGPVLSP |
2.52
|
-11.87 |
1.54 |
|
GPVLSPMNKV |
6.04
|
-9.05 |
4.36 |
|
VPTHSPYAQP |
6.57
|
-10.04 |
3.37 |
| P15941 |
ASKSTPFSIP |
6.32
|
-8.33 |
5.08 |
|
GVTSAPDTRP |
7.06
|
-7.97 |
5.44 |
|
APDNKPAPGS |
7.15
|
-7.28 |
6.13 |
| Q9NYB9 |
PPTQKPPSPP |
3.51
|
-11.27 |
2.14 |
|
PPPPPPVEEP |
4.32
|
-11.71 |
1.70 |
|
PVSDTPPPPP |
4.58
|
-10.29 |
3.12 |
| Q15303 |
PPAYTPMSGN |
3.40
|
-10.88 |
2.53 |
|
APERSPRGEL |
4.91
|
-10.18 |
3.23 |
|
GHSPPPAYTP |
7.29
|
-8.13 |
5.28 |
| P78527 |
SPDYPNPMFE |
5.71
|
-9.47 |
3.94 |
|
PDYPNPMFEH |
6.73
|
-4.31 |
9.10 |
|
PTSDPAANLH |
7.46
|
-6.11 |
7.30 |
| Q09472 |
PPNSMPPYLP |
3.51
|
-12.16 |
1.25 |
|
APVPTPPAMP |
3.82
|
-11.32 |
2.09 |
|
QPGLQPPTMP |
4.68
|
-11.39 |
2.02 |
|
