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Matrix information:
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ADAN-name: 1AZE2.PDB
Scoring matrix: 1AZE2_mat
Uniprot code: P62993
Genome source: Homo sapiens
Wild-type ligand: VPPPVPPRRR
Foldx wt ligand score: 4.05
Foldx random average score for Homo sapiens: 9.188 Available information for P62993 in MINT (Nov 2008):
Nš of interacting proteins: 64
Proteins belonging to other specie: 6
Nš of interactions described: 157
Interactions with other species: 28
Genome scanning information:
Subcellular location: False
Proteins in genome Homo sapiens: 70890
Proteins located in other compartments: 0
Proteins considered as fragments or having non-standard amino acids: 22829
Total scanned proteins: 48061
Total fragments: 22104514
Proteins after random average filtering: 48043
Total fragments: 12038742
Proteins after disorder filtering: 35539
Total fragments: 974248
Proteins after pattern filtering: 25665
Total fragments: 300584
Proteins after MINT filtering: 35
Total fragments: 1165
Prediction of know targets:
| Ligand peptide |
Sequence |
Foldx score |
ΔGbinding |
ΔΔG |
| Reference wt |
VPPPVPPRRR |
4.05
|
-9.29 |
0.00 |
| Best peptides |
DWFPMPRMGR |
0.00
|
-9.72 |
-0.43 |
| |
|
|
|
|
| Interactors |
|
|
|
|
| O43609 |
SPPTRPVPGH |
5.70
|
-7.00 |
2.29 |
| Q13177 |
KPPAPPVRMS |
5.23
|
-7.06 |
2.23 |
|
PPAPPVRMSS |
6.09
|
-6.89 |
2.40 |
|
FPSGTPALNA |
6.97
|
-5.28 |
4.01 |
| Q07890 |
IPPPLPPRKK |
3.60
|
-9.84 |
-0.55 |
|
DPPAIPPRQP |
4.07
|
-9.55 |
-0.26 |
|
PAPPVPPRQN |
4.31
|
-8.89 |
0.40 |
| P35968 |
GPQPLPIHVG |
4.74
|
-7.08 |
2.21 |
|
PQPLPIHVGE |
9.06
|
-3.77 |
5.52 |
| P07949 |
GHEPGEPRGI |
6.45
|
-7.53 |
1.76 |
|
PGEPRGIKAG |
6.79
|
-5.41 |
3.88 |
|
HEPGEPRGIK |
7.35
|
-4.70 |
4.59 |
| O43561 |
PPLSQPDLLP |
5.83
|
-6.95 |
2.34 |
|
QPDLLPIPRS |
6.06
|
-6.71 |
2.58 |
|
AAPSAPALST |
6.12
|
-6.03 |
3.26 |
| Q13094 |
KKPPVPKHGW |
3.64
|
-8.48 |
0.81 |
|
RNFPLPLPNK |
5.02
|
-7.00 |
2.29 |
|
RPLPQPALLP |
5.29
|
-8.79 |
0.50 |
| Q05193 |
APPGVPSRSG |
4.22
|
-8.79 |
0.50 |
|
QVPSRPNRAP |
4.29
|
-8.48 |
0.81 |
|
PVPSRPGASP |
6.56
|
-5.69 |
3.60 |
| Q13191 |
DPFGMPMLDL |
3.65
|
-7.41 |
1.88 |
|
DPLQIPHLSL |
4.22
|
-8.47 |
0.82 |
|
PPKPRPRRTA |
4.41
|
-8.19 |
1.10 |
| Q07912 |
DKPQVPPRVP |
4.49
|
-9.49 |
-0.20 |
|
GGVKKPTYDP |
4.60
|
-7.81 |
1.48 |
|
GARPPPPRAT |
4.65
|
-9.96 |
-0.67 |
| Q15303 |
FAPERSPRGE |
5.07
|
-5.92 |
3.37 |
|
PPPAYTPMSG |
6.33
|
-6.36 |
2.93 |
|
PPAYTPMSGN |
7.18
|
-4.34 |
4.95 |
| P00533 |
PLNPAPSRDP |
5.27
|
-7.34 |
1.95 |
|
SVPKRPAGSV |
5.80
|
-5.68 |
3.61 |
|
GLEGCPTNGP |
5.88
|
-5.46 |
3.83 |
| P11137 |
PSYPRTPHTP |
5.52
|
-7.77 |
1.52 |
|
KQFDSPMPSP |
6.57
|
-5.21 |
4.08 |
|
SPGPLTPMRE |
6.63
|
-7.47 |
1.82 |
| P22681 |
SLPPVPPRLD |
3.94
|
-9.62 |
-0.33 |
|
PRPDVPRLGS |
3.96
|
-8.53 |
0.76 |
|
GAESRPQRRP |
4.17
|
-9.63 |
-0.34 |
| P18031 |
PPPPRPPKRI |
5.19
|
-9.43 |
-0.14 |
|
DLEPPPEHIP |
5.62
|
-7.58 |
1.71 |
|
PPPRPPKRIL |
6.29
|
-6.78 |
2.51 |
| P29353 |
PPPPCPGREL |
5.01
|
-9.13 |
0.16 |
|
LPVGQPVGGD |
5.52
|
-6.18 |
3.11 |
|
DGAAMPESGP |
5.78
|
-5.70 |
3.59 |
| Q9H0H5 |
PLPCIPTLIG |
5.18
|
-7.10 |
2.19 |
|
DGPPGPVKKT |
6.12
|
-6.23 |
3.06 |
|
STPQTPDIKV |
6.17
|
-5.76 |
3.53 |
| P63010 |
TFAPSPTPAV |
7.27
|
-4.75 |
4.54 |
|
SFIPSSVPAT |
7.47
|
-4.51 |
4.78 |
|
LDLGPPVNVP |
7.91
|
-5.51 |
3.78 |
| P48634 |
RPPPMPPMNF |
2.89
|
-9.93 |
-0.64 |
|
PPLPPPHRGP |
3.78
|
-9.79 |
-0.50 |
|
PPQFPPYRGM |
3.93
|
-8.39 |
0.90 |
| Q13905 |
PPFQLPLGGH |
4.23
|
-6.25 |
3.04 |
|
PPPALPPKKR |
4.93
|
-8.55 |
0.74 |
|
PKPPLPGIRV |
5.36
|
-8.15 |
1.14 |
| P50570 |
PLIPVPVGAA |
4.60
|
-7.31 |
1.98 |
|
IPPGVPSRRP |
4.63
|
-9.76 |
-0.47 |
|
QIPSRPVRIP |
4.64
|
-9.01 |
0.28 |
| Q07889 |
VPPPVPPRRR |
4.05
|
-10.52 |
-1.23 |
|
SPPAIPPRQP |
4.14
|
-8.19 |
1.10 |
|
AGPPVPPRQS |
4.39
|
-9.31 |
-0.02 |
| Q07666 |
RQPPLPHRSR |
3.53
|
-8.97 |
0.32 |
|
SVRQTPSRQP |
5.13
|
-6.70 |
2.59 |
|
VPPPPTVRGA |
5.15
|
-7.66 |
1.63 |
| Q9UKW4 |
PCVPKPVDYS |
6.52
|
-6.11 |
3.18 |
|
PCPCVPKPVD |
7.14
|
-6.08 |
3.21 |
|
VKPCPCVPKP |
8.81
|
-4.89 |
4.40 |
| Q9UQC2 |
VYIPMSPGAH |
4.94
|
-6.65 |
2.64 |
|
PRPPKPSQAE |
5.44
|
-6.90 |
2.39 |
|
SEDNYVPMNP |
6.06
|
-6.73 |
2.56 |
| P58107 |
PREPGPAGRG |
6.72
|
-5.75 |
3.54 |
|
QDAWRGPREP |
7.69
|
-6.53 |
2.76 |
|
QDARRGPREP |
8.15
|
-6.55 |
2.74 |
| P48023 |
PPLPLPPLKK |
4.33
|
-9.83 |
-0.54 |
|
PLPPLKKRGN |
5.24
|
-6.20 |
3.09 |
|
PLPLPPLKKR |
5.83
|
-7.89 |
1.40 |
| Q13480 |
SSPKTPPRRP |
4.97
|
-8.53 |
0.76 |
|
PRPPKPHPAH |
5.13
|
-7.67 |
1.62 |
|
NTYQIPRTFP |
5.58
|
-6.28 |
3.01 |
| P27986 |
KKISPPTPKP |
6.09
|
-6.32 |
2.97 |
|
PRPPRPLPVA |
6.30
|
-6.98 |
2.31 |
|
PKPPKPTTVA |
6.37
|
-6.51 |
2.78 |
| O43597 |
TVVPRPGLKP |
4.25
|
-9.28 |
0.01 |
|
CTYPRPLPSD |
5.26
|
-8.11 |
1.18 |
|
GLKPAPRPST |
6.55
|
-7.08 |
2.21 |
| Q13444 |
PSWPLPNIGG |
4.06
|
-7.43 |
1.86 |
|
PAKPPPPRKP |
4.37
|
-9.69 |
-0.40 |
|
ERPGPPQRAL |
4.80
|
-7.00 |
2.29 |
| Q06124 |
PCTPTPPCAE |
7.81
|
-5.65 |
3.64 |
|
HGVPSDPGGV |
8.04
|
-5.50 |
3.79 |
|
DGDPNEPVSD |
8.31
|
-4.07 |
5.22 |
| Q8WV28 |
GKKPTTPLKT |
5.66
|
-4.60 |
4.69 |
|
PPPEKAPMVN |
5.92
|
-7.02 |
2.27 |
|
KKPTTPLKTT |
6.63
|
-6.60 |
2.69 |
| P04626 |
GLQSLPTHDP |
4.66
|
-6.59 |
2.70 |
|
CPDPAPGAGG |
5.85
|
-4.51 |
4.78 |
|
QGFFCPDPAP |
5.90
|
-5.79 |
3.50 |
| P21860 |
PVPIMPTAGT |
5.46
|
-6.52 |
2.77 |
|
PHPPRPSSLE |
6.42
|
-5.86 |
3.43 |
|
TPLSPPGLEE |
6.85
|
-6.40 |
2.89 |
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